[Effects of beta 1-adrenoblocker bisoprolol on endothelial dysfunction in patients with stable angina pectoris in combination with chronic obstructive pulmonary disease].

Abstract

AIM:

To study effects of a cardioselective beta-adrenoblocker bisoprolol on vascular wall endothelium and external respiration function in stable angina of effort combined with chronic obstructive pulmonary disease (COPD).

MATERIAL AND METHODS:

Endothelial function and external respiration were studied before and after 4-week treatment with bisoprolol in 36 patients with stable angina and COPD using assessment of endothelium-dependent vasodilatation (EDVD) and concentrations of nitric oxide metabolites.

RESULTS:

Significant improvement of endothelial function was achieved due to bisoprolol 4-week treatment which did not affect external respiration function.

CONCLUSION:

Bisoprolol is effective and safe drug in the treatment of stable angina combined with COPD. It can noticeably improve endothelial function.

• Authors: N Iu Grigor'eva, E G Sharabrin, A N Kuznetsov, K V Mazalov, K N Kontorshchikova, E F Koroleva
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 81 Issue 3 Pg. 28-31 ( 2009) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 19459418 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Bisoprolol

Topics

• Adrenergic beta-Antagonists (administration & dosage, therapeutic use)
• Aged
• Angina Pectoris (complications, diagnosis, drug therapy)
• Bisoprolol (administration & dosage, therapeutic use)
• Endothelium, Vascular (drug effects, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Pulmonary Disease, Chronic Obstructive (complications, diagnosis, drug therapy)