Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures.

Abstract

The vitamin E of palm oil, unlike most other vegetal fats, consists largely of tocotrienols (TT), products previously reported as having antioxidant and tumor-inhibitory properties. A tocotrienols containing palm oil, in the form of liposomes entrapping dosages of 0.5-0.05 microgTT/mL, was studied in combined treatments with doxorubicin (30 min before drug administration). The IC(50) values of doxorubicin, at 24 h, showed that its cytotoxic effects were decreased by palm oil, in a dose effect relationship (p < 0.01, ANOVA), in both normal (Hfl-1, Huvec) and tumor (HepG2, Mls) cells. These results demonstrated an unselective protective activity of tocotrienols, in vitro, on some normal and tumor cultured cells treated with doxorubicin.

• Authors: Ion Dan Postescu, Piroska Virag, Marcela Achim, Eva Fischer-Fodor
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 24 Issue 1 Pg. 154-6 (Jan 2010) ISSN: 1099-1573 [Electronic] England
• PMID: 19449337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2009 John Wiley & Sons, Ltd.

Chemical References

• Liposomes
• Plant Oils
• Tocotrienols
• Palm Oil
• Doxorubicin

Topics

• Cell Line, Tumor
• Cell Proliferation
• Cell Survival
• Dose-Response Relationship, Drug
• Doxorubicin (pharmacology)
• Humans
• Inhibitory Concentration 50
• Liposomes (pharmacology)
• Palm Oil
• Plant Oils (pharmacology)
• Tocotrienols (pharmacology)