Neuropeptide VF-associated satiety involves mu and kappa but not delta subtypes of opioid receptors in chicks.

Abstract

Neuropeptide VF (NPVF) induces satiety through hypothalamic interactions; however, the central mechanism that mediates these effects is poorly understood. Therefore, this study was conducted to explore some possible opioid receptor associated mechanisms of NPVF-induced satiety using chicks as models. Co-injection of NPVF and a mu opioid receptor antagonist (beta-funaltrexamine, FNA) did not have an additive suppressive effect on food intake compared to NPVF and FNA when injected alone. Contrary, co-injection of NPVF and a delta opioid receptor antagonist (ICI-174,864, ICI) caused a greater reduction in food intake than when both were injected alone. Co-injection of NPVF and a kappa opioid receptor antagonist (nor-binaltorphimine, BNI) did not cause an additive suppressive effect on food intake than when the two were injected alone. A reversal of neuropeptide Y and beta-endorphin induction of food intake occurred when NPVF was co-injected. These results support that NPVF-induced satiety is mediated through mu and kappa but not delta subtypes of opioid receptors, and their ligands including neuropeptide Y and beta-endorphin. Thus, NPVF-associated anorexia may be mediated via modulation of the chick's innate opioid-associated orexigenic system.

• Authors: Mark A Cline, Lindsay N Sliwa
• Journal: Neuroscience letters (Neurosci Lett) Vol. 455 Issue 3 Pg. 195-8 (May 22 2009) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 19429120 (Publication Type: Journal Article)

Chemical References

• Intracellular Signaling Peptides and Proteins
• Narcotic Antagonists
• Neuropeptide Y
• Neuropeptides
• Opioid Peptides
• Orexins
• Receptors, Opioid
• Receptors, Opioid, delta
• Receptors, Opioid, kappa
• Receptors, Opioid, mu
• neuropeptide VF
• beta-Endorphin

Topics

• Animals
• Appetite Regulation (drug effects, physiology)
• Brain (drug effects, metabolism)
• Chickens
• Drug Interactions (physiology)
• Hypothalamus (drug effects, metabolism)
• Intracellular Signaling Peptides and Proteins (metabolism)
• Narcotic Antagonists (pharmacology)
• Neuropeptide Y (metabolism)
• Neuropeptides (metabolism, pharmacology)
• Opioid Peptides (metabolism)
• Orexins
• Receptors, Opioid (drug effects, metabolism)
• Receptors, Opioid, delta (drug effects, metabolism)
• Receptors, Opioid, kappa (drug effects, metabolism)
• Receptors, Opioid, mu (drug effects, metabolism)
• Satiety Response (drug effects, physiology)
• beta-Endorphin (metabolism)