Neuropeptide Y

A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.

Also Known As:

Networked: 2091 relevant articles (19 outcomes, 205 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Herzog, Herbert: 22 articles (06/2014 - 05/2002)
2.	Morris, Margaret J: 15 articles (01/2013 - 10/2003)
3.	Yada, Toshihiko: 12 articles (08/2015 - 04/2003)
4.	Beck-Sickinger, Annette G: 12 articles (07/2015 - 09/2005)
5.	Zukowska, Zofia: 11 articles (06/2013 - 02/2003)
6.	Meguid, Michael M: 11 articles (09/2008 - 01/2003)
7.	Mathé, Aleksander A: 10 articles (02/2015 - 01/2004)
8.	During, Matthew J: 9 articles (03/2010 - 03/2004)
9.	Tilan, Jason U: 8 articles (03/2015 - 07/2007)
10.	Sainsbury, Amanda: 8 articles (06/2014 - 01/2002)

Related Diseases

1.	AIDS-Related Complex (ARC) 11/01/2003 - "Neuropeptide Y (NPY)-producing neurons in the hypothalamic arcuate nucleus (ARC) have been implicated in GH feedback in several studies in rats. " 03/01/2014 - "Within the hypothalamic arcuate nucleus (ARC), fasting increased cfos activation in ∼25% of neuropeptide Y neurons, which was terminated 1 hour after refeeding. " 04/01/2013 - "on 45% or 60% fat diet were heavier and fatter than controls, and had reduced neuropeptide Y (NPY) gene expression in the ARC. " 01/01/2013 - "In support of these findings, double-label immunohistochemistry indicated substantial coexpression of neuropeptide Y (NPY)- and Arc-immunoreactivity in Fos-positive neurons. " 11/01/2012 - "Orexigenic neuropeptide Y expressing ARC neurons are activated by food deprivation and inhibited by feeding in a nutrient-dependent manner. "
2.	Body Weight (Weight, Body) 05/02/2006 - "A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice." 02/01/1989 - "Organ weights, body weight and neuropeptide Y (NPY) content in brain regions were determined at the end of the study. " 10/01/2015 - "Orexigenic actions mediated by neuropeptide-Y (NPY) promote body weight regulation. " 08/01/2012 - "The neuropeptide Y (NPY) has been suggested to act as a major regulator of emotional processes and body weight. " 06/10/2012 - "Plasma neuropeptide Y levels relate cigarette smoking and smoking cessation to body weight regulation."
3.	Seizures (Seizure) 03/01/1998 - "[Seizure-linked hippocampal plasticity and protection against excitotoxicity: possible role of neuropeptide-y]." 11/22/2002 - "Previous studies show that neuropeptide Y (NPY) inhibits in vitro seizures in rodent hippocampus. " 01/01/2002 - "Functional studies in epileptic tissue indicate that neuropeptide Y and some of its peptide analogs potently inhibit seizure activity. " 07/07/2000 - "Recent studies reported changes in neuropeptide Y (NPY) expression induced by seizures in the experimental epileptic models. " 01/01/2015 - "Many mouse models of the disease also present neuronal network hypersynchrony, as evidenced by higher susceptibility to pharmacologically-induced seizures, electroencephalographic seizures accompanied by spontaneous interictal spikes and expression of markers of chronic seizures such as neuropeptide Y ectopic expression in mossy fibers. "
4.	Weight Loss (Weight Reduction) 05/01/2001 - "The aim of the study is the assessment whether weight loss treatment with adrenergic modulation drugs modifies neuropeptide Y (NPY) plasma concentration in obese women. " 06/01/2003 - "Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats." 05/01/1991 - "Increased central hypothalamic levels of neuropeptide Y in food-restricted rats suggest that this peptide may help to defend body weight by stimulating eating after weight loss." 12/20/2005 - "Despite numerous experiments showing that administration of neuropeptide Y (NPY) to rodents stimulates feeding and obesity, whereas acute interference with NPY signaling disrupts feeding and promotes weight loss, NPY-null mice have essentially normal body weight regulation. " 05/01/1994 - "Hypothalamic neuropeptide Y (NPY) may be involved in the hyperphagia that follows food deprivation associated with significant weight loss. "
5.	Hypertension (High Blood Pressure) 09/01/2003 - "The aim of this study was to assess changes of plasma concentration of neuropeptide Y in patients with hypertension after exercise. " 07/01/1995 - "The aim or the study was to assess plasma neuropeptide Y immunoreactivity concentration (NPY-ir) during dynamic exercise in pts with different stages of essential hypertension (ESH). " 06/01/1994 - "Our study shows that plasma ET-1 and neuropeptide Y levels are elevated in patients with essential hypertension compared with a control group. " 09/01/1993 - "Thus, the present study indicates that neuropeptide Y is involved only slightly in the maintenance of high blood pressure in SHR." 01/01/2015 - "We hypothesized that Neuropeptide Y (NPY), which is a potent mitogenic peptide, participates in modulating proliferation and migration of VSMCs during hypertension in pregnancy. "

Related Drugs and Biologics

1.	Somatostatin (Somatotropin Release-Inhibiting Factor)
2.	Leptin
3.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
4.	Substance P
5.	Calcitonin Gene-Related Peptide
6.	Neuropeptides
7.	Pro-Opiomelanocortin (Proopiomelanocortin)
8.	Norepinephrine (Noradrenaline)
9.	Galanin
10.	Hormones

Related Therapies and Procedures

1.	Denervation
2.	Intranasal Administration
3.	Drug Therapy (Chemotherapy)
4.	Surgical Instruments (Clip)
5.	Transplantation (Transplant Recipients)