A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.

Abstract

Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) and COX-2 are involved in cellular processes such as inflammation, apoptosis, and tumorigenesis. To address the relationship between COX-2 and NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/+) mice, and COX-2(-/-) mice. While COX-2 expression is highly induced in tumor tissue, NAG-1 expression is reduced. Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression. The results suggest that a possible inverse relationship exists between the expression of NAG-1 and COX-2 in tumor formation of colon tissue.

• Authors: Genzo Iguchi, Kali Chrysovergis, Seong-Ho Lee, Seung Joon Baek, Robert Langenbach, Thomas E Eling
• Journal: Cancer letters (Cancer Lett) Vol. 282 Issue 2 Pg. 152-8 (Sep 18 2009) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 19375854 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• GDF15 protein, human
• Gdf15 protein, mouse
• Growth Differentiation Factor 15
• Pyrazoles
• Sulfonamides
• Ptgs2 protein, mouse
• Cyclooxygenase 2
• PTGS2 protein, human
• Celecoxib
• Dinoprostone

Topics

• Animals
• Celecoxib
• Colorectal Neoplasms (etiology)
• Cyclooxygenase 2 (genetics)
• Dinoprostone (pharmacology)
• Gene Expression Regulation (drug effects)
• Growth Differentiation Factor 15 (genetics)
• Humans
• Intestinal Polyps (metabolism)
• Mice
• Mice, Inbred C57BL
• Pyrazoles (pharmacology)
• Sulfonamides (pharmacology)