Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders.

Abstract

Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement therapy-including caveolin mimetic peptides-is ongoing.

• Authors: Isabelle Mercier, Jean-Francois Jasmin, Stephanos Pavlides, Carlo Minetti, Neal Flomenberg, Richard G Pestell, Philippe G Frank, Federica Sotgia, Michael P Lisanti
• Journal: Laboratory investigation; a journal of technical methods and pathology (Lab Invest) Vol. 89 Issue 6 Pg. 614-23 (Jun 2009) ISSN: 1530-0307 [Electronic] United States
• PMID: 19333235 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Caveolins
• Peptides

Topics

• Adult Stem Cells (metabolism)
• Animals
• Breast Neoplasms (drug therapy, metabolism)
• Cardiomyopathies (metabolism)
• Caveolae (metabolism)
• Caveolins (biosynthesis, genetics, physiology)
• Diabetes Mellitus (drug therapy, metabolism)
• Humans
• Hypertension, Pulmonary (drug therapy, metabolism)
• Male
• Mice
• Muscular Dystrophies (drug therapy, metabolism)
• Mutation
• Peptides (therapeutic use)
• Prostatic Neoplasms (drug therapy, metabolism)
• Signal Transduction