Peroxisome proliferator-activated receptor gamma negatively regulates allergic rhinitis in mice.

Abstract

BACKGROUND:

Peroxisome proliferator-activated receptor gamma(PPAR-gamma) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils. The present study was aimed at investigating the effects of PPAR-gamma agonist on nasal symptoms and eosinophil accumulations in nasal mucosa by using a murine allergic rhinitis model. Furthermore, we examined the expression of PPAR-gamma in the nasal mucosa in mice.

METHODS:

BALB/c mice were sensitized and challenged intranasally with ovalbumin. Ciglitazone, a PPAR-gamma agonist, was administered orally 6 hours before each nasal challenge.

RESULTS:

Administration of PPAR-gamma agonist significantly decreased the number of nasal rubs, nasal histamine responsiveness, serum IgE, IL-5 production from the spleen, and eosinophilic infiltration in the nasal mucosa. Furthermore, PPAR-gamma was expressed in eosinophils and epithelial cells in the nasal mucosa by immunohistochemistry.

CONCLUSIONS:

PPAR-gamma was expressed in eosinophils and epithelial cells in the nasal mucosa. Also, the oral administration of ciglitazone is effective in upper airway allergic inflammation in mice.

• Authors: Naoko Fukui, Kohei Honda, Eiko Ito, Kazuo Ishikawa
• Journal: Allergology international : official journal of the Japanese Society of Allergology (Allergol Int) Vol. 58 Issue 2 Pg. 247-53 (Jun 2009) ISSN: 1440-1592 [Electronic] England
• PMID: 19307774 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Interleukin-13
• Interleukin-5
• PPAR gamma
• Thiazolidinediones
• Immunoglobulin E
• Histamine
• Interferon-gamma
• Ovalbumin
• ciglitazone

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology, therapeutic use)
• Behavior, Animal (drug effects)
• Eosinophils (metabolism, pathology)
• Epithelial Cells (metabolism)
• Female
• Histamine (pharmacology)
• Immunoglobulin E (blood, immunology)
• Interferon-gamma (metabolism)
• Interleukin-13 (metabolism)
• Interleukin-5 (metabolism)
• Mice
• Mice, Inbred BALB C
• Nasal Mucosa (drug effects, metabolism, pathology)
• Ovalbumin (immunology, pharmacology)
• PPAR gamma (agonists, metabolism)
• Rhinitis, Allergic, Perennial (drug therapy, immunology, metabolism, pathology)
• Sneezing (drug effects)
• Spleen (drug effects, metabolism)
• Thiazolidinediones (administration & dosage, pharmacology, therapeutic use)