Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.

Abstract

Vitamin D deficiency and adipocytokines have been implicated in the etiology of aging-related diseases such as cancer, osteoporosis, and diseases of the cardiovascular system. The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear. Utilizing plasma samples from women in a previous intervention study, we measured plasma 25-OH-VitD, leptin, adiponectin, PTH, and lipid levels. We observed strong positive associations for leptin with PTH, gamma -tocopherol, and body mass index (BMI) and inverse associations with 25-OH-VitD and adiponectin. Although commonly accepted that vitamin D deficiency causes hyperparathyroidism, we observed this association primarily in individuals with elevated leptin levels, suggesting that leptin may be an important modifier of this effect consistent with 25-OH-VitD-mediated inhibition of leptin. Leptin was highly correlated with the BMI/25-OH-VitD ratio (r = 0.80; P < 0.0001), consistent with a model in which BMI (adiposity) and 25-OH-VitD are the primary determinants of circulating leptin and PTH levels. This model may explain the failure of some studies to observe elevated PTH in vitamin D deficient adolescents and provides important insight into epidemiological studies exploring the associations of these individual biomarkers with chronic disease risk and mortality.

• Authors: Micah Maetani, Gertraud Maskarinec, Adrian A Franke, Robert V Cooney
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 61 Issue 2 Pg. 225-31 ( 2009) ISSN: 1532-7914 [Electronic] United States
• PMID: 19235038 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adiponectin
• Leptin
• Lipids
• Parathyroid Hormone
• Vitamin D
• Carotenoids
• 25-hydroxyvitamin D

Topics

• Adiponectin (blood)
• Adult
• Body Mass Index
• Carotenoids
• Diet
• Female
• Fruit
• Humans
• Hyperparathyroidism (blood)
• Leptin (blood)
• Lipids (blood)
• Parathyroid Hormone (blood)
• Regression Analysis
• Risk Factors
• Vegetables
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (blood)