Recent data have redefined the concept of
inflammation as a critical component of
tumor progression. However, there has been little development on cases where
inflammation on or near a
wound and a
tumor exist simultaneously. Therefore, this pilot study aims to observe the impact of a
wound on a
tumor, to build a new mouse
tumor model with a manufactured
surgical wound representing acute
inflammation, and to evaluate the relationship between acute
inflammation or wound healing and the process of
tumor growth. We focus on the two phases that are present when acute
inflammation influences
tumor. In the early phase, inhibitory effects are present. The process that produces these effects is the functional reaction of IFN-gamma secretions from a
wound inflammation. In the latter phase, the inhibited
tumor is made resistant to IFN-gamma through the release of
TGF-beta to balance the inflammatory factor effect on the
tumor cells. A pair of
cytokines IFN-gamma/
TGF-beta established a new balance to protect the
tumor from the interference effect of the
inflammation. The
tumor was made resistant to IFN-gamma through the release of
TGF-beta to balance the inflammatory effect on the
tumor cells. This balance mechanism that occurred in the
tumor cells increased proliferation and invasion. In vitro and in vivo experiments have confirmed a new view of clinical surgery that will provide more detailed information on the evaluation of
tumors after surgery. This study also provides a better understanding of the relationship between
tumor and
inflammation, as well as
tumor cell attacks on inflammatory factors.