Mitochondrial function is related to alterations at brain SPECT in depressed patients.

Abstract

INTRODUCTION:

99mTc-d,l-hexamethylpropylene amine oxime (99mTc-HMPAO) retention in brain is proportional to cerebral blood flow and related to both the local hemodynamic state and to the cellular content of reduced glutathione. Alterations of the regional distribution of 99mTc-HMPAO retention, with discrepant results, have been reported at functional brain imaging of unipolar depression. Since mitochondrial involvement has been reported in depressed patients, the aim of the study was to explore whether the 99mTc-HMPAO retention at single-photon emission computed tomography in depressed patients may relate to different levels of mitochondrial function.

METHODS:

All patients had audiological and muscular symptoms, somatic symptoms that are common in depression. Citrate synthase (CS) activity assessed in muscle mitochondria correlated strongly with the activities of three mitochondrial respiratory chain enzymes and was used as a marker of mitochondrial function. K-means clustering performed on CS grouped eight patients with low and 11 patients with normal CS. Voxel-based analysis was performed on the two groups by statistical parametric mapping.

RESULTS:

Voxel-based analysis showed significantly higher 99mTc-HMPAO retention in the patients with low CS compared with the patients with normal CS in the posterior and inferior frontal cortex, the superior and posterior temporal cortex, the somato-sensory cortex, and the associative parietal cortex.

CONCLUSION:

Low muscle CS in depressed patients is related to higher regional 99mTc-HMPAO retention that may reflect cerebrovascular adaptation to impaired intracellular metabolism and/or intracellular enzymatic changes, as previously reported in mitochondrial disorder. Mitochondrial dysfunction in varying proportions of the subjects may explain some of the discrepant results for 99mTc-HMPAO retention in depression.

• Authors: Ann Gardner, Dario Salmaso, Davide Nardo, Federica Micucci, Flavio Nobili, Alejandro Sanchez-Crespo, Hans Jacobsson, Stig A Larsson, Marco Pagani
• Journal: CNS spectrums (CNS Spectr) Vol. 13 Issue 9 Pg. 805-14 (Sep 2008) ISSN: 1092-8529 [Print] United States
• PMID: 18849900 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Technetium Tc 99m Exametazime
• Citrate (si)-Synthase
• Electron Transport Complex I

Topics

• Adult
• Brain (diagnostic imaging)
• Brain Mapping
• Cerebral Cortex (diagnostic imaging)
• Citrate (si)-Synthase (metabolism)
• Depressive Disorder (diagnostic imaging)
• Dominance, Cerebral (physiology)
• Electron Transport Complex I (physiology)
• Female
• Frontal Lobe (diagnostic imaging)
• Humans
• Image Processing, Computer-Assisted
• Imaging, Three-Dimensional
• Male
• Middle Aged
• Mitochondria, Muscle (diagnostic imaging)
• Technetium Tc 99m Exametazime (pharmacokinetics)
• Tomography, Emission-Computed, Single-Photon