Oximes

03/01/2006 - "Therefore, to find new oximes able to sufficiently reactivate inhibited AChE (regardless of the type of OPCs) is still very important task for medicinal chemistry with the aim to improve the efficacy of antidotal treatment of the acute poisonings mentioned. "
01/01/2005 - "Current evidence is insufficient to indicate whether oximes are harmful or beneficial in the management of acute organophosphorus pesticide poisoning. "
04/20/2007 - "The experience gathered with the experimental and therapeutic approaches to human poisoning by OP pesticides may be helpful when oximes have to be selected against nerve agents."
05/18/1990 - "Imidazolium oximes are useful in the treatment of organophosphorus agent poisoning. "
03/01/2006 - "In this study, we undertook a meta-analysis by reviewing all clinical trials to evaluate the efficacy of oximes in the management of organophosphate poisoning. "

01/15/2011 - "O-(2,4-Dichlorobenzyl) oximes 8a, 16a and 20a were significantly effective in delaying the onset of the PTZ-evoked seizures at the dose of 30mg/kg in kindled animals. "
01/01/2010 - "Thus, tertiary oximes reactivated AChE in the brain, improved survival, and terminated seizures following GB intoxication."
02/01/2015 - "Decontamination, meticulous supportive care, aggressive antimuscarinic therapy, seizure control, and administration of oximes are cornerstones of management. "
01/15/2011 - "The most effective compounds in delaying seizures were 7-chlorochromanone-O-(2,4-dichlorobenzyl) oximes 8a and 20a. "
01/01/2010 - "In contrast, none of the quaternary oximes prevented or stopped GB-induced seizures. "

04/01/2014 - "To understand the nature of acidity in Sulfated Zr-MCM-41, the efficiency of the materials is investigated in dehydration of Oximes. "
03/07/2014 - "Organoselenium-catalyzed mild dehydration of aldoximes: an unexpected practical method for organonitrile synthesis."
03/07/2014 - "Areneselenenic acids (ArSeOH), readily generated from diaryl diselenides and H2O2 by in situ oxidation, were found to be effective and reusable catalysts for dehydration of aldoximes, leading to a practical and scalable preparation of useful organonitriles under mild conditions. "
10/01/2003 - "In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes."
12/04/2015 - "Dehydration of Aldoximes Using PhSe(O)OH as the Pre-Catalyst in Air."

01/01/1971 - "The anticholinesterase hypothermia in the rat: its practical application in the study of the central effectiveness of oximes."
11/01/2010 - "The cerebral protection achieved through administration of oximes is only partial, without major impact on the antagonism of OP-induced seizures, hypothermia and respiratory center inhibition. "
11/01/2010 - "The functional parameters/therapeutic effects following the penetration of oximes through BBB, more precisely the antagonism of OP-induced seizures and hypothermia, prevention of brain damage and respiratory center protection, leading to the final end-point, the survival of intoxicated organisms, are of high interest. "
01/01/1971 - "The comparative efficacy of the five oximes and the effectiveness of cholinesterase inhibitors in producing hypothermia in other animal species, including man, are discussed."
01/01/1971 - "From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes. "

09/01/2014 - "Young Thy1-aSyn mice exhibit motor deficits that differ from parkinsonism and are established before the onset of treatment; these deficits were not improved by cholesterol oximes. "