Abstract | OBJECTIVE: METHODS: RESULTS: Forty patients with liver enzyme abnormalities were identified. Major clinical diagnostic groups were drug-induced (n = 4), viral hepatitis ( hepatitis B or C and cytomegalovirus; n = 8), nonalcoholic fatty liver disease ( NAFLD; n = 8), autoimmune hepatitis (AIH; n = 6), primary biliary cirrhosis (PBC; n = 3), and miscellaneous [n = 11; liver involvement from infection (2), cryptogenic cirrhosis (2), lymphoma (1), and indeterminate (6)]. There were no differences in mean age, total and direct bilirubin, or aspartate aminotransferase and alkaline phosphatase levels. Alanine aminotransferase levels were higher in the miscellaneous group. Biopsies were performed in 20 patients and showed changes of NAFLD (n = 5), AIH (n = 4), PBC (n = 3), hepatitis C (n = 3), and cryptogenic cirrhosis (n = 2), and 1 each with phenytoin-induced liver injury, hepatic granulomas due to systemic candidiasis, and lymphomatous involvement of the liver. The median followup was 44 months (range 10-576). The estimated 5-year serious liver disease-free survival was 93% (95% confidence interval 84%-100%). Eight patients died. Mortality was not directly related to liver disease in any patient. CONCLUSION:
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Authors | Vaidehi R Chowdhary, Cynthia S Crowson, John J Poterucha, Kevin G Moder |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 35
Issue 11
Pg. 2159-64
(Nov 2008)
ISSN: 0315-162X [Print] Canada |
PMID | 18793002
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Antinuclear
(blood)
- Biopsy
- Female
- Hepatic Encephalopathy
(mortality, pathology)
- Humans
- Hypertension, Portal
(mortality, pathology)
- Liver Cirrhosis
(mortality, pathology)
- Liver Diseases
(mortality, pathology)
- Lupus Erythematosus, Systemic
(immunology, mortality)
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Young Adult
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