Androgen deprivation therapy and risk for diabetes and cardiovascular disease in prostate cancer survivors.

Abstract

Gonadotropin-releasing hormone (GnRH) agonists are the mainstay of treatment for recurrent and metastatic prostate cancer. GnRH agonists are also an important part of therapy for many men with localized or locally advanced prostate cancer. Although GnRH agonists improve survival in certain settings, they involve adverse effects including vasomotor flushing, obesity, and osteoporosis. This article describes the evidence that GnRH agonists increase risk for diabetes and cardiovascular disease and reviews the potential mechanisms for treatment-related morbidity.

• Authors: Matthew R Smith
• Journal: Current urology reports (Curr Urol Rep) Vol. 9 Issue 3 Pg. 197-202 (May 2008) ISSN: 1534-6285 [Electronic] United States
• PMID: 18765113 (Publication Type: Journal Article, Review)

Chemical References

• Gonadotropin-Releasing Hormone

Topics

• Cardiovascular Diseases (chemically induced)
• Diabetes Mellitus (chemically induced)
• Gonadotropin-Releasing Hormone (agonists)
• Humans
• Male
• Prostatic Neoplasms (drug therapy)
• Risk Factors
• Survivors