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SNAP-25 genotype influences NAA/Cho in left hippocampus.

Abstract
The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). Thirty-eight patients with schizophrenia, BD or obsessive-compulsive disorder and 17 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped. Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of N-acetyl-aspartate (NAA)/choline-containing compounds (Cho) in the left hippocampus compared to the group of individuals with the homozygous TT genotype. The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus.
AuthorsHarald Scherk, Martin Backens, Peter Zill, Thomas Schneider-Axmann, Thomas Wobrock, Juliana Usher, Wolfgang Reith, Peter Falkai, Hans-Jürgen Möller, Brigitta Bondy, Oliver Gruber
JournalJournal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 115 Issue 11 Pg. 1513-8 (Nov 2008) ISSN: 0300-9564 [Print] Austria
PMID18726138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • SNAP25 protein, human
  • Synaptosomal-Associated Protein 25
  • Aspartic Acid
  • DNA
  • N-acetylaspartate
  • Choline
Topics
  • Adult
  • Aspartic Acid (analogs & derivatives, metabolism)
  • Bipolar Disorder (metabolism)
  • Choline (metabolism)
  • DNA (genetics)
  • Female
  • Genotype
  • Hippocampus (chemistry, metabolism)
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Obsessive-Compulsive Disorder (metabolism)
  • Polymorphism, Single Nucleotide
  • Reverse Transcriptase Polymerase Chain Reaction
  • Schizophrenia (metabolism)
  • Synaptosomal-Associated Protein 25 (genetics)

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