Abstract |
The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). Thirty-eight patients with schizophrenia, BD or obsessive-compulsive disorder and 17 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped. Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of N-acetyl-aspartate (NAA)/ choline-containing compounds (Cho) in the left hippocampus compared to the group of individuals with the homozygous TT genotype. The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus.
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Authors | Harald Scherk, Martin Backens, Peter Zill, Thomas Schneider-Axmann, Thomas Wobrock, Juliana Usher, Wolfgang Reith, Peter Falkai, Hans-Jürgen Möller, Brigitta Bondy, Oliver Gruber |
Journal | Journal of neural transmission (Vienna, Austria : 1996)
(J Neural Transm (Vienna))
Vol. 115
Issue 11
Pg. 1513-8
(Nov 2008)
ISSN: 0300-9564 [Print] Austria |
PMID | 18726138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- SNAP25 protein, human
- Synaptosomal-Associated Protein 25
- Aspartic Acid
- DNA
- N-acetylaspartate
- Choline
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Topics |
- Adult
- Aspartic Acid
(analogs & derivatives, metabolism)
- Bipolar Disorder
(metabolism)
- Choline
(metabolism)
- DNA
(genetics)
- Female
- Genotype
- Hippocampus
(chemistry, metabolism)
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Obsessive-Compulsive Disorder
(metabolism)
- Polymorphism, Single Nucleotide
- Reverse Transcriptase Polymerase Chain Reaction
- Schizophrenia
(metabolism)
- Synaptosomal-Associated Protein 25
(genetics)
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