Abstract | OBJECTIVE:
Schizophrenia is associated with various abnormalities in the immune system. Suppression of inflammatory cytokines by cigarette smoke is well-established. The purpose of this study was to determine any differences in cytokine profiles in smokers and nonsmokers with schizophrenia and whether there were any relationships among altered cytokine profiles and psychopathological symptoms. MATERIALS AND METHODS: RESULTS: The positive PANSS symptoms were lower in smokers than nonsmokers, while the negative symptoms were lower in those who smoked more cigarettes. Cytokine levels were positively correlated: IL-2 level with IL-6 and IL-6 with both IL-8 and TNF-alpha. Both IL-2 and IL-6, but not IL-8 or TNF-alpha, were significantly lower in smokers than nonsmokers (p < 0.002; p < 0.01). Lower IL-2 levels correlated with fewer negative symptoms and with smoking more cigarettes. CONCLUSIONS: The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be associated with nicotine-induced suppression of some inflammatory cytokines.
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Authors | Xiang Yang Zhang, Lian Yuan Cao, Cai Song, Gui Ying Wu, Da Chun Chen, Ling Yan Qi, Fan Wang, Mei Hong Xiu, Song Chen, Yingyang Zhang, Lin Lu, Therese A Kosten, Thomas R Kosten |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 201
Issue 3
Pg. 383-9
(Dec 2008)
ISSN: 0033-3158 [Print] Germany |
PMID | 18719893
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antipsychotic Agents
- Interleukins
- Tumor Necrosis Factor-alpha
- Clozapine
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Topics |
- Age Factors
- Antipsychotic Agents
(therapeutic use)
- Chronic Disease
- Clozapine
(blood, therapeutic use)
- Diagnostic and Statistical Manual of Mental Disorders
- Drug Administration Schedule
- Humans
- Interleukins
(blood, chemistry)
- Male
- Middle Aged
- Psychiatric Status Rating Scales
- Schizophrenia
(blood, diagnosis, drug therapy)
- Smoking
(blood)
- Smoking Cessation
(psychology)
- Time Factors
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(blood, chemistry)
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