Two new triterpene saponins from the anti-inflammatory saponin fraction of Ilex pubescens root.

Abstract

The saponin fraction from the ethanolic extracts of the root of Ilex pubescens Hook. et Arn. (Ilexaceae) was found to exhibit potent anti-inflammatory effects on carrageenan-induced paw edema in rats. Two novel triterpene saponins, pubescenosides C and D (1 and 2, resp.), together with five known saponins were isolated from this saponin fraction. The structures of 1 and 2 were elucidated as (20beta)-3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranosyl]ursa-12,18-dien-28-oic acid 28-O-beta-D-glucopyranosyl ester, and (20beta)-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranosyl]ursa- 12,18-dien-28-oic acid 28-O-beta-D-glucopyranosyl ester, respectively, on the basis of chemical and spectroscopic data. Five known saponins isolated from the saponin fraction were identified as ilexsaponin B(1), B(2), B(3), A(1), and chikusetsusaponin IV(a).

• Authors: Jing-Rong Wang, Hua Zhou, Zhi-Hong Jiang, Liang Liu
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 5 Issue 7 Pg. 1369-76 (Jul 2008) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 18649303 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Saponins
• pubescenoside C
• pubescenoside D
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents (isolation & purification, therapeutic use)
• Carrageenan
• Edema (chemically induced, drug therapy)
• Ilex (chemistry)
• Nuclear Magnetic Resonance, Biomolecular
• Plant Roots (chemistry)
• Rats
• Saponins (chemistry, isolation & purification, therapeutic use)