Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus.

Abstract

AIMS:

The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients.

METHOD:

Forty type 2 diabetic patients (21 males and 19 females, 52.8+/-11.8 years old; mean+/-S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay.

RESULTS:

Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5+/-3.8vs. 4.1+/-1.9 microg/ml, p=0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p=0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p=0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p=0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p=0.13).

CONCLUSIONS:

Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.

• Authors: Kyoko Tanimura, Yasushi Nakajima, Mototugu Nagao, Akira Ishizaki, Toshiko Kano, Taro Harada, Fumitaka Okajima, Mariko Sudo, Hideki Tamura, Shinya Ishii, Hitoshi Sugihara, Shizuya Yamashita, Akira Asai, Shinichi Oikawa
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 81 Issue 3 Pg. 338-44 (Sep 2008) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 18632179 (Publication Type: Journal Article)

Chemical References

• Apolipoprotein B-48
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Triglycerides

Topics

• Adult
• Aged
• Apolipoprotein B-48 (blood)
• Blood Pressure
• Carotid Stenosis (blood, physiopathology)
• Circadian Rhythm
• Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
• Diabetic Angiopathies (blood, physiopathology)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Male
• Middle Aged
• Triglycerides (blood)