Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.

Abstract

Although gadolinium has been the dominant paramagnetic metal for MR paramagnetic contrast agents, the recent association of this lanthanide with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alternative metals for MR molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle. In this report, Mn(III) nanobialys are characterized as MR molecular imaging agents for targeted detection of fibrin, a major biochemical feature of thrombus. A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.

• Authors: Dipanjan Pan, Shelton D Caruthers, Grace Hu, Angana Senpan, Mike J Scott, Patrick J Gaffney, Samuel A Wickline, Gregory M Lanza
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 130 Issue 29 Pg. 9186-7 (Jul 23 2008) ISSN: 1520-5126 [Electronic] United States
• PMID: 18572935 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Micelles
• Organometallic Compounds
• Manganese
• Biotin
• Doxorubicin
• Fibrin
• Camptothecin

Topics

• Biotin (chemistry)
• Camptothecin (administration & dosage, chemistry)
• Doxorubicin (administration & dosage, chemistry)
• Drug Delivery Systems (methods)
• Fibrin (analysis, chemistry)
• Humans
• Magnetic Resonance Angiography (methods)
• Manganese (chemistry)
• Micelles
• Microscopy, Atomic Force
• Nanoparticles (chemistry)
• Organometallic Compounds (chemistry)