Association of interleukin-6 (-174G>C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: an exploratory study.

Abstract

Chronic inflammation plays a role in transformation from normal cell to malignant state. Interleukin-6 (IL-6) regulates inflammation and various physiological processes. IL-6 promoter polymorphism (-174G>C) is associated with transcription differences in vitro and in vivo. High expression of IL-6 may result in oxidative DNA damage and enhance risk of carcinogenesis. Therefore, we aimed to evaluate association of IL-6 -174G>C polymorphism with predisposition to esophageal cancer (EC) in 369 subjects (168 patients with EC and 201 controls). We observed significant association of IL-6 -174C non-carrier genotype with risk of EC, (OR=2.29; P=0.001), with squamous cell carcinoma (SCC) histology (OR=2.26; P=0.001) and tumor at upper and lower anatomical locations (OR=5.97; P=0.009 and OR=2.34; P=0.034). Patients having IL-6 -174C non-carrier genotype were at elevated risk of metastasis (OR=2.49; P=0.005). In conclusion, IL-6 -174G>C gene polymorphism may confer high risk for EC and its clinical characteristics.

• Authors: Rohit Upadhyay, Meenu Jain, Shaleen Kumar, Uday Chand Ghoshal, Balraj Mittal
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 128 Issue 2 Pg. 199-204 (Aug 2008) ISSN: 1521-7035 [Electronic] United States
• PMID: 18502691 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6

Topics

• Adenocarcinoma (genetics, immunology)
• Carcinoma, Squamous Cell (genetics, immunology)
• Esophageal Neoplasms (genetics, immunology)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-6 (genetics)
• Male
• Middle Aged
• Neoplasm Metastasis
• Polymorphism, Genetic
• Promoter Regions, Genetic (genetics)
• Risk Factors