[Neurohumoral and functional determinants of destabilization in patients with acute forms of ischemic heart disease].

Abstract

A study of neurohumoral and functional determinants of the advance of Ischemic heart disease in 39 patients with unstable stenocardia with positive results of loading tests (transesophageal electrocardiostimulation and veloergometry) allowed to reveal a significant reduction of the coronary reserve and regional dysfunction of the myocardium that interrelated with changes of the prostacyclin/thromboxane balance, increase of vasopressin with unchanged angiotensin II value and increased marker of the functional state of thrombocytes--beta-thromboglobulin. These changes may be one of the leading links in the pathogenesis of destabilization.

• Authors: V K Tashchuk, S Iu Savitskiĭ, V A Shumakov, L I Popova, I E Malinovskaia, M N Reĭko
• Journal: Vrachebnoe delo (Vrach Delo) Issue 6 Pg. 28-30 (Jun 1991) ISSN: 0049-6804 [Print] Ukraine
• Vernacular Title: Neĭrogumoral'nye i funktsional'nye determinanty destabilizatsii u bol'nykh s ostrymi formami ishemicheskoĭ bolezni serdtsa.
• PMID: 1832506 (Publication Type: English Abstract, Journal Article)

Chemical References

• beta-Thromboglobulin
• Vasopressins
• Angiotensin II
• Fibrinopeptide A
• Thromboxane A2
• Epoprostenol

Topics

• Acute Disease
• Angiotensin II (metabolism)
• Coronary Disease (blood, diagnosis, physiopathology)
• Epoprostenol (metabolism)
• Fibrinopeptide A (metabolism)
• Humans
• Physical Exertion
• Radioimmunoassay
• Thromboxane A2 (metabolism)
• Vasopressins (metabolism)
• beta-Thromboglobulin (metabolism)