CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

Abstract	At present few vaccine candidates exists against potentially pandemic influenza virus infections. We provide compelling evidence that a targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope, CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity. This novel CTA1-3M2e-DD fusion protein combines adjuvant and a conserved influenza A antigen in a promising candidate for a universal anti-influenza vaccine.
Authors	Dubravka Grdic Eliasson, Karim El Bakkouri, Karin Schön, Anna Ramne, Els Festjens, Björn Löwenadler, Walter Fiers, Xavier Saelens, Nils Lycke
Journal	Vaccine (Vaccine) Vol. 26 Issue 9 Pg. 1243-52 (Feb 26 2008) ISSN: 0264-410X [Print] Netherlands
PMID	18243429 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Adjuvants, Immunologic Antibodies, Viral CTA1-DD protein, recombinant Immunoglobulin A Immunoglobulin G Influenza Vaccines M2 protein, Influenza A virus M2e-HBc influenza vaccine Recombinant Fusion Proteins Viral Matrix Proteins Cholera Toxin
Topics	Adjuvants, Immunologic (administration & dosage) Amino Acid Sequence Animals Antibodies, Viral (blood) B-Lymphocytes (immunology) Cholera Toxin (administration & dosage, immunology) Female Immunity, Mucosal Immunization Immunoglobulin A (analysis) Immunoglobulin G (blood) Influenza A Virus, H1N1 Subtype (genetics, pathogenicity) Influenza A Virus, H3N2 Subtype (genetics, pathogenicity) Influenza Vaccines (administration & dosage, genetics, immunology) Male Mice Molecular Sequence Data Orthomyxoviridae Infections (immunology, prevention & control) Reassortant Viruses (genetics, pathogenicity) Recombinant Fusion Proteins (administration & dosage, genetics, immunology) Viral Matrix Proteins (administration & dosage, chemistry, genetics, immunology)

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