Abstract | OBJECTIVE: METHODS: Forty-two adult female Sprague-Dawley rats were divided into two groups: Group A for investigation of ischemia related to SDH and its treatment, and Group B for investigation of cerebral edema. Both groups were further divided into five subgroups, i.e. for sham operations, formation of SDH and treatment with saline, MK-801 and memantine. Treatment of cerebral edema could not be investigated because formation of cerebral edema could not be proven statistically. For evaluation of ischemia, the ratio of ischemic area/the total brain area was calculated as percentages in coronal slices of the rats' brains. RESULTS: In all of the evaluated slices, statistical analysis showed that treatment with MK-801 as well as memantine reduced ischemia caused by SDH. DISCUSSION: Our study showed that memantine, which is already considered as a safe treatment alternative for other central nervous system ( CNS) diseases, can be useful in the treatment of acute SDH as well.
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Authors | Altay Sencer, Osman Arica, Talat Kirin, Askin Görgülü, Damla Aktan |
Journal | Neurological research
(Neurol Res)
Vol. 30
Issue 5
Pg. 497-503
(Jun 2008)
ISSN: 0161-6412 [Print] England |
PMID | 18241528
(Publication Type: Journal Article)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Dizocilpine Maleate
- Memantine
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Topics |
- Animals
- Brain Edema
(drug therapy, etiology)
- Brain Ischemia
(drug therapy, etiology, pathology)
- Disease Models, Animal
- Dizocilpine Maleate
(therapeutic use)
- Excitatory Amino Acid Antagonists
(therapeutic use)
- Female
- Functional Laterality
- Hematoma, Subdural, Acute
(complications)
- Memantine
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Statistics, Nonparametric
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