[Systemic neurolymphomatosis complicated in diffuse large B-cell lymphoma].

Abstract

A 73-year-old woman was diagnosed with diffuse large B-cell lymphoma of the uterus (Stage IVB). After 3 courses of CHOP therapy, right abducens nerve paralysis appeared and was diagnosed as central nervous system infiltration with lymphoma cells. Although partial remission was obtained by chemotherapy with methotrexate, numbness and muscle weakness of all four limbs appeared asymmetrically and progressed subacutely. Nerve conduction velocity examination revealed mononeuritis multiplex, but we could not reach a final diagnosis. Steroid pulse therapy, chemotherapy including high-dose methotrexate, and radiation therapy were ineffective. On autopsy, histological examination of the peripheral nerves revealed systemic neurolymphomatosis.

• Authors: Takayoshi Tachibana, Naoto Tomita, Tomomi Ueda, Jun Katoh, Sachiya Takemura, Jun Taguchi, Yoji Suzuki, Masao Kasahara, Yoshiaki Ishigatsubo, Hiroyuki Fujita
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 48 Issue 12 Pg. 1563-6 (Dec 2007) ISSN: 0485-1439 [Print] Japan
• PMID: 18203518 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Female
• Humans
• Lymphoma, Large B-Cell, Diffuse (pathology)
• Nervous System (pathology)
• Uterine Neoplasms (pathology)