Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR 677 TT in the meta-analysis (odds ratio (OR) = 1.52, 95% confidence interval (CI): 1.31, 1.77) and pooled analysis (OR = 1.49, 95% CI: 1.14, 1.95). No association resulted for MTHFR 1298 CC (meta-OR = 0.94, 95% CI: 0.65, 1.35; pooled OR = 0.90, 95% CI: 0.69, 1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR = 2.05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.

• Authors: Stefania Boccia, Rayjean Hung, Gualtiero Ricciardi, Francesco Gianfagna, Matthias P A Ebert, Jing-Yuan Fang, Chang-Ming Gao, Tobias Götze, Francesco Graziano, Marina Lacasaña-Navarro, Dongxin Lin, Lizbeth López-Carrillo, You-Lin Qiao, Hongbing Shen, Rachael Stolzenberg-Solomon, Toshiro Takezaki, Yu-Rong Weng, Fang Fang Zhang, Cornelia M van Duijn, Paolo Boffetta, Emanuela Taioli
• Journal: American journal of epidemiology (Am J Epidemiol) Vol. 167 Issue 5 Pg. 505-16 (Mar 01 2008) ISSN: 1476-6256 [Electronic] United States
• PMID: 18162478 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Folic Acid
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Asia (epidemiology)
• Europe (epidemiology)
• Folic Acid (genetics)
• Genetic Variation
• Genotype
• Humans
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• North America (epidemiology)
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Risk Factors
• Stomach Neoplasms (epidemiology, genetics)