Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice.

Abstract

The interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation were studied. Mice were induced with colitis and exposed to cigarette smoke (CS) and/or SC236 (a COX-2 inhibitor). Results indicated that CS did not alter acute colonic inflammation. Addition of SC236 abolished the induction of proliferation and oxidative damage by colitis. Chronic SC236 treatment abolished the promoting effect of CS on colonic adenoma formation, via suppression of COX-2- and VEGF-mediated proliferation and angiogenesis, and reversed bcl-2-mediated inhibition of apoptosis by CS. To conclude, COX-2 inhibitor could be an implication on cancer prevention in smokers with chronic colitis.

• Authors: Edgar Shiu-Lam Liu, Yi-Ni Ye, Vivian Yvonne Shin, William Ka-Kei Wu, Benjamin Chun-Yu Wong, Chi-Hin Cho
• Journal: Cancer investigation (Cancer Invest) Vol. 25 Issue 8 Pg. 750-7 (Dec 2007) ISSN: 1532-4192 [Electronic] England
• PMID: 18058473 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
• Pyrazoles
• Sulfonamides
• Dextran Sulfate
• Cyclooxygenase 2

Topics

• Adenoma (etiology, prevention & control)
• Animals
• Apoptosis
• Cell Proliferation
• Colitis, Ulcerative (complications)
• Colonic Neoplasms (etiology, prevention & control)
• Cyclooxygenase 2 (physiology)
• Dextran Sulfate
• Male
• Mice
• Mice, Inbred BALB C
• Pyrazoles (therapeutic use)
• Smoking (adverse effects)
• Sulfonamides (therapeutic use)