Abstract | INTRODUCTION: METHODS: In a prospective study, IR was determined using both insulin tolerance test and HOMA in 22 patients with NAFLD. Rate constant for insulin tolerance test (KITT) was calculated using the formula KITT (%/min) = 0.693/t(1/2), where t(1/2) was calculated from the slope of plasma glucose concentration during 3-15 minutes after administration of intravenous insulin. IR was assessed using HOMA as the product of fasting insulin (microU/L) and fasting plasma glucose (mmol/L) levels divided by 22.5. RESULTS: All the 22 patients had IR. Results of KITT and HOMA-IR for determining IR showed a fair correlation (r = 0.55; p = 0.03). CONCLUSIONS:
Insulin tolerance test may be a useful method for assessing IR in patients with NAFLD.
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Authors | Ajay Duseja, Kiran K Thumburu, Ashim Das, R K Dhiman, Y K Chawla, S Bhadada, Anil Bhansali |
Journal | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
(Indian J Gastroenterol)
2007 Jul-Aug
Vol. 26
Issue 4
Pg. 170-3
ISSN: 0254-8860 [Print] India |
PMID | 17986744
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Fatty Liver, Alcoholic
(diagnosis, physiopathology)
- Female
- Homeostasis
(physiology)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Male
- Middle Aged
- Prospective Studies
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