Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia.

Abstract

A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of alpha-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning.

• Authors: Masataka Ishimura, Shouichi Ohga, Yoshihisa Nagatoshi, Jun Okamura, Tatsuro Tajiri, Kenichi Kohashi, Yoshinao Oda, Hidetoshi Takada, Toshiro Hara
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 11 Issue 8 Pg. 945-9 (Dec 2007) ISSN: 1397-3142 [Print] Denmark
• PMID: 17976134 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Anemia, Aplastic (surgery)
• Bone Marrow Transplantation (methods)
• Child, Preschool
• Fatal Outcome
• Follow-Up Studies
• Hepatoblastoma (diagnosis, etiology)
• Humans
• Liver Neoplasms (diagnosis, etiology)
• Living Donors
• Male
• Siblings
• Time Factors
• Tomography, X-Ray Computed