Systemic ciclosporin and tacrolimus in dermatology.

Abstract

Ciclosporin and tacrolimus are calcineurin inhibiting immunosuppressant agents useful in the treatment of immune-mediated inflammatory dermatoses. Available data and clinical experience demonstrate ciclosporin's efficacy in treating psoriasis, atopic dermatitis, pyoderma gangrenosum, lichen planus, autoimmune bullous disease (in combination with corticosteroids), recalcitrant chronic idiopathic urticaria, and chronic dermatitis of the hands and feet. Although the role of topical tacrolimus in atopic dermatitis is well established, such experience with the oral formulation of tacrolimus has been limited. However, there are several case studies and anecdotal reports of the successful use of oral tacrolimus in various dermatoses. In this article we discuss the utility of systemic ciclosporin and tacrolimus in dermatology.

• Authors: V Madan, C E M Griffiths
• Journal: Dermatologic therapy (Dermatol Ther) 2007 Jul-Aug Vol. 20 Issue 4 Pg. 239-50 ISSN: 1396-0296 [Print] United States
• PMID: 17970889 (Publication Type: Journal Article, Review)

Chemical References

• Calcineurin Inhibitors
• Immunosuppressive Agents
• Cyclosporine
• Tacrolimus

Topics

• Animals
• Calcineurin Inhibitors
• Cyclosporine (adverse effects, therapeutic use)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Practice Guidelines as Topic
• Skin Diseases (drug therapy)
• Tacrolimus (adverse effects, therapeutic use)