Oxcarbazepine in neuropathic pain.

Abstract

Neuropathic pain is a frequent condition that can result from a variety of underlying conditions and is frequently chronic and difficult to treat. A number of drugs are used to treat neuropathic pain, including anticonvulsants and antidepressants. Oxcarbazepine, a recently introduced antiepileptic drug, was found to possess antineuralgic properties in animal models of neuropathic pain. Several double-blind, placebo-controlled trials have evaluated oxcarbazepine in painful diabetic neuropathy and trigeminal neuralgia. There is good evidence that oxcarbazepine is effective in relieving the pain associated with trigeminal neuralgia. Its efficacy in treating painful diabetic neuropathy is less clear; however, it seems to be useful when tolerated at doses of 1800 mg/day.

• Authors: Wassim Nasreddine, Ahmad Beydoun
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 16 Issue 10 Pg. 1615-25 (Oct 2007) ISSN: 1744-7658 [Electronic] England
• PMID: 17922625 (Publication Type: Journal Article, Review)

Chemical References

• Analgesics, Non-Narcotic
• Anticonvulsants
• Carbamazepine
• Oxcarbazepine

Topics

• Analgesics, Non-Narcotic (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Animals
• Anticonvulsants (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Carbamazepine (adverse effects, analogs & derivatives, pharmacokinetics, pharmacology, therapeutic use)
• Diabetic Neuropathies (drug therapy)
• Humans
• Neuralgia (drug therapy)
• Oxcarbazepine