The role of intracellular amyloid beta in Alzheimer's disease.

Abstract

Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.

• Authors: Meng Li, Liying Chen, Daniel Hong Seng Lee, Long-Chuan Yu, Yan Zhang
• Journal: Progress in neurobiology (Prog Neurobiol) Vol. 83 Issue 3 Pg. 131-9 (Oct 2007) ISSN: 0301-0082 [Print] England
• PMID: 17889422 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Amyloid beta-Peptides

Topics

• Alzheimer Disease (metabolism, pathology)
• Amyloid beta-Peptides (metabolism)
• Animals
• Humans
• Intracellular Fluid (metabolism)
• Neurons (cytology, metabolism, pathology)