Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.

Abstract

Cefazolin injection (3000 mg/kg, i.v.) in mice showed several behavioral excitations such as wild running, jumping, rolling, and finally undergoing severe convulsions followed by death. It's lower doses (500-2000 mg/kg, i.v.) were unable to produce any convulsions or behavioral excitations in mice. However, cefazolin (500 or 1000 mg/kg, i.v.) when administered before different doses of pentylenetetrazol (PTZ; 40 or 60 mg/kg, i.p.) or picrotoxin (PTX; 4 or 8 mg/kg, i.p.), it produced severe tonic-clonic convulsions in mice. The convulsions or behavioral excitations produced by 3000 mg/kg, i.v. cefazolin was also reversed by different doses of diazepam (0.5-2 mg/kg, i.p.) further proving the GABAergic modulatory effect of cefazolin. The results conclude the pro-convulsant action of cefazolin on PTZ- or PTX-induced convulsions, and further confirm the clinical reports.

• Authors: Kiran Kumar Akula, Ashish Dhir, S K Kulkarni
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 45 Issue 8 Pg. 720-5 (Aug 2007) ISSN: 0019-5189 [Print] India
• PMID: 17877149 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Convulsants
• GABA-A Receptor Agonists
• Picrotoxin
• Cefazolin
• Pentylenetetrazole

Topics

• Animals
• Anti-Bacterial Agents
• Behavior, Animal (drug effects)
• Cefazolin (toxicity)
• Convulsants (toxicity)
• GABA-A Receptor Agonists
• Male
• Mice
• Mice, Inbred Strains
• Pentylenetetrazole (toxicity)
• Picrotoxin (toxicity)
• Seizures (chemically induced)