Does botulinum toxin improve the function of the patient with spasticity after stroke?

Abstract

Post-stroke spasticity is an important cause of disability in adults, due to muscle hyperactivity, which results in limb stiffness and muscle spasm. The prognosis for these patients depends on several features such as early management and adequate physical therapy to avoid muscle shortening, pain, and their consequences. Although several papers have shown that intramuscular injections of botulinum toxin type A (BT-A) decreases spasticity in post-stroke patients, few authors have demonstrated functional improvement after this therapy. In order to assess if individualized BT-A injections improves upper limb function in post-stroke spastic patients, we prospectively followed 20 consecutive patients of 18 years of age or more with spastic hemiparesis secondary to stroke. Fulg-Meyer scale modified for upper limbs, measure of functional independence (MFI), Ashworth modified scale, and goniometry were applied in the beginning of the investigation and in the 16th and 32nd weeks. BT-A was applied at baseline and in the 16th week. All subjects were submitted to rehabilitation therapy. All patients showed improvement according to Ashworth modified scale and increase in the range of motion, which were sustained until the 32nd week (p<0.05). The assessment of the first three parameters of the Fulg-Meyer scale and the evaluations of the motor part of the Functional Independence Measure showed statistically improvement until the end of the study. We conclude that proper choice of muscles and individualized doses of BT-A can improve function in selected post-stroke patients.

• Authors: Eduardo Cardoso, Glícia Pedreira, Antônio Prazeres, Nildo Ribeiro, Ailton Melo
• Journal: Arquivos de neuro-psiquiatria (Arq Neuropsiquiatr) Vol. 65 Issue 3A Pg. 592-5 (Sep 2007) ISSN: 0004-282X [Print] Germany
• PMID: 17876396 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Activities of Daily Living
• Adult
• Analysis of Variance
• Botulinum Toxins, Type A (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Muscle Spasticity (drug therapy, etiology, rehabilitation)
• Muscle Stretching Exercises
• Neuromuscular Agents (administration & dosage)
• Prospective Studies
• Range of Motion, Articular
• Stroke (complications)
• Stroke Rehabilitation
• Treatment Outcome
• Upper Extremity