[Hypereosinophilic syndrome--recent developments in diagnosis and treatment].

Abstract

In case of eosinophilia persisting for more than 6 months a diagnosis of hypereosinophilic syndrome (HES) should be considered if secondary causes of eosinophilia ca be ruled out. Recent studies on the pathogenesis of HES revealed that the syndrome previously coined "idiopathic HES" is comprised of pathogenetically distinct subtypes which are defined by molecular, immunophenotypic or clinical markers. Eosinophilia in HES can be caused by increased production or survival of eosinophils due to cytokines such as interleukin-5 (IL-5) or clonal expansion due to mutations. Distinction of these pathogenetically different subtypes of HES is clinically relevant as new targeted treatment approaches are available for some of these subtypes, such as tyrosine kinase inhibitors for the FIP1L1-PDGFRA-positive myeloproliferativer subtype, immunomodulators such as interferon-alpha or monoclonal antibodies against IL-5 for FIP1L1-PDGFRA-negative patients.

• Authors: B Hellmich, K Holl-Ulrich, W L Gross
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 132 Issue 37 Pg. 1892-6 (Sep 2007) ISSN: 1439-4413 [Electronic] Germany
• Vernacular Title: Hypereosinophiles Syndrom: aktueller Stand der Diagnostik und Therapie.
• PMID: 17823882 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Benzamides
• Glucocorticoids
• Immunosuppressive Agents
• Interferon-alpha
• Piperazines
• Protein Kinase Inhibitors
• Pyrimidines
• Tumor Necrosis Factor-alpha
• Imatinib Mesylate
• mepolizumab

Topics

• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents (therapeutic use)
• Benzamides
• Glucocorticoids (therapeutic use)
• Humans
• Hypereosinophilic Syndrome (classification, diagnosis, etiology, therapy)
• Hypersensitivity (complications)
• Imatinib Mesylate
• Immunosuppressive Agents (therapeutic use)
• Interferon-alpha (therapeutic use)
• Lung Diseases (complications)
• Neoplasms (complications)
• Parasitic Diseases (complications)
• Piperazines (therapeutic use)
• Protein Kinase Inhibitors (therapeutic use)
• Pyrimidines (therapeutic use)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)
• Vasculitis (complications)