Effects of crude extracts of various plants on infectious bovine rhinotracheitis virus-plaque production.

Abstract

Extracts of 28 plants were tested without demonstable antiviral activity in an agar-overlay plaque-reduction antiviral assay system, using infectious bovine rhinotracheitis virus and bovine endocardial cell cultures. Ethanolic extract of Narcissus tazetta L bulb elicited antiviral activity by inhibition of viral plaque formation. Antiviral activity was demonstrated against infectious bovine rhinotracheitis and equine rhinopneumonitis viruses. Narcissus tazetta L bulb did not directly inactivate the virus extracellularly. The extract exhibited only limited toxicity to rapidly multiplying bovine endocardial cells at plaque-inhibitory levels and was not cytoxic to preformed confluent cell monolayers. Narcissus extract did not induce the formation of drug-resistant viral strains.

• Authors: C L Kelling, I A Schipper, L J Schermeister, J P Vacik
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 37 Issue 2 Pg. 215-8 (Feb 1976) ISSN: 0002-9645 [Print] United States
• PMID: 176907 (Publication Type: Journal Article)

Chemical References

• Plant Extracts

Topics

• Cells, Cultured
• Herpesvirus 1, Bovine (drug effects, growth & development)
• Herpesvirus 1, Equid (drug effects, growth & development)
• Plant Extracts (pharmacology)