Abstract | BACKGROUND: METHODS: The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed -1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters. RESULTS: CONCLUSIONS: Our results demonstrate an independent risk for -1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome.
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Authors | Loredan Stefan Niculescu, Jamila Fruchart-Najib, Jean-Charles Fruchart, Anca Sima |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 45
Issue 9
Pg. 1133-9
( 2007)
ISSN: 1434-6621 [Print] Germany |
PMID | 17635078
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- APOA5 protein, human
- Apolipoprotein A-V
- Apolipoproteins A
- Insulin
- Triglycerides
- Cholesterol
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Topics |
- Alleles
- Apolipoprotein A-V
- Apolipoproteins A
(genetics, physiology)
- Atherosclerosis
(genetics)
- Cardiovascular Diseases
(genetics)
- Cholesterol
(metabolism)
- Gene Frequency
- Genetic Variation
- Homozygote
- Humans
- Insulin
(metabolism)
- Metabolic Syndrome
(genetics)
- Multigene Family
- Obesity
(genetics)
- Polymorphism, Genetic
- Risk Factors
- Triglycerides
(metabolism)
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