Abstract | OBJECTIVE: To examine the possibility of detecting p53 protein in the supernatant of induced sputum (IS) of workers exposed to crystalline silica. METHODS: Personal interviews were used to obtain demographic data, occupational and exposure histories, and health habits of the study participants. Sputum samples were collected from all subjects. RESULTS: The all-male study cohort included 35 workers (mean age 43.8 years) exposed to silica and 7 unexposed workers (34.7 years, P < 0.05). The mean duration of exposure was 13.4 years, and the range of exposure levels to silica was 0.02 to 0.33 ppm. The mean level of p53 protein was higher in the exposed group compared with in the unexposed group (76.47 pg/mL and 62.43 pg/mL, respectively). CONCLUSIONS:
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Authors | Judith Shaham, Elizabeth Fireman, Avital Korenstein-Ilan, Yehuda Lerman |
Journal | Journal of occupational and environmental medicine
(J Occup Environ Med)
Vol. 49
Issue 7
Pg. 730-5
(Jul 2007)
ISSN: 1076-2752 [Print] United States |
PMID | 17622845
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Suppressor Protein p53
- Novobiocin
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Topics |
- Adult
- Cohort Studies
- Humans
- Interviews as Topic
- Israel
- Male
- Middle Aged
- Novobiocin
(poisoning)
- Occupational Exposure
- Sputum
- Tumor Suppressor Protein p53
(analysis)
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