Paclitaxel and cisplatin with concurrent radiotherapy followed by surgery in locally advanced thymic carcinoma.

Abstract

Thymic carcinoma is a rare neoplasm with a poor prognosis. We report the clinical course of a patient who received complete surgical resection after effective induction treatment. A 72-year-old woman with advanced thymic carcinoma (squamous cell carcinoma, stage IVb) was considered as nonresectable due to invasion of neighboring organs and mediastinal lymph node metastasis. Two cycles of chemotherapy, consisting of paclitaxel (180 mg/m2) plus cisplatin (80 mg/m2), combined with thoracic radiotherapy (total 54 Gy) were performed concurrently and complete radical resection could then be performed. She is currently alive and ambulatory and has remained disease-free for two years. This multimodal treatment may be a good treatment option for locally advanced thymic carcinoma.

• Authors: Minoru Fukuda, Yasushi Obase, Naoyuki Miyashita, Yoshihiro Kobashi, Keiji Mohri, Shiro Ueno, Makio Hayama, Katsuhiko Shimizu, Hironori Nishimura, Masao Nakata, Mikio Oka
• Journal: Anticancer research (Anticancer Res) 2007 May-Jun Vol. 27 Issue 3B Pg. 1601-4 ISSN: 0250-7005 [Print] Greece
• PMID: 17595782 (Publication Type: Case Reports, Journal Article)

Chemical References

• Paclitaxel
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Female
• Humans
• Paclitaxel (administration & dosage, therapeutic use)
• Radiography, Thoracic
• Thymoma (drug therapy, radiotherapy, surgery)
• Thymus Neoplasms (drug therapy, radiotherapy, surgery)
• Treatment Outcome