Chlamydia psittaci infection and clinicopathologic analysis of ocular adnexal lymphomas in Korea.

Abstract

Ocular adnexal lymphoma (OAL) is a mostly extranodal marginal zone lymphoma (EMZL). Recent findings have suggested an association between Chlamydia psittaci (Cp) infection and OAL. We sought to confirm this issue and to analyze the clinicopathologic characteristics of OAL in Korea. Between 1993 and 2004, 33 OAL cases were identified at the Asan Medical Center, Seoul, Korea. DNA was extracted from paraffin-embedded tissues, and touchdown enzyme time release polymerase chain reaction was performed to identify three Chlamydia species (Cp, C. tracomatis, and C. pneumoniae). The same procedures were also performed in 21 samples from patients with non-neoplastic ocular adnexal disease (NNOAD). All OAL cases were EMZL. Cp DNA was detected in 26/33 (79%) OAL samples compared with 5/21 (23%) NNOAD samples (P < 0.001). With a median follow-up of 38.5 months (range: 1-105 months), the 5-year progression-free survival (PFS) and overall survival (OS) rates of OAL patients were 72% and 93%, respectively. Clinicopathologic characteristics, recurrence rate, PFS, and OS were not associated with Cp infection. Our study demonstrates an association between OAL and Cp infection in Korea, suggesting that Cp plays a role as a causative antigen in Korean OAL patients.

• Authors: Changhoon Yoo, Min-Hee Ryu, Jooryung Huh, Ji Hyun Park, Hye Jin Kang, Hyo Sook Ahn, Yongjae Lee, Myoung Joon Kim, Hyoungnam Lee, Tae Won Kim, Heung Moon Chang, Jae-Lyun Lee, Yoon-Koo Kang
• Journal: American journal of hematology (Am J Hematol) Vol. 82 Issue 9 Pg. 821-3 (Sep 2007) ISSN: 0361-8609 [Print] United States
• PMID: 17570512 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2007 Wiley-Liss, Inc

Chemical References

• DNA, Bacterial
• Cytarabine
• Vincristine
• Etoposide
• Dexamethasone
• Doxorubicin
• Cyclophosphamide
• Cisplatin
• Prednisone

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Case-Control Studies
• Chlamydophila psittaci (genetics, isolation & purification)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Cytarabine (administration & dosage)
• DNA, Bacterial (isolation & purification)
• Dexamethasone (administration & dosage)
• Disease-Free Survival
• Dose-Response Relationship, Drug
• Dose-Response Relationship, Radiation
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Eye Neoplasms (complications, genetics, microbiology, pathology)
• Follow-Up Studies
• Humans
• Korea (epidemiology)
• Lymphoma, B-Cell (complications, drug therapy, genetics, microbiology, pathology, radiotherapy, surgery)
• Polymerase Chain Reaction
• Prednisone (administration & dosage)
• Psittacosis (complications, epidemiology)
• Retrospective Studies
• Secondary Prevention
• Sequence Analysis, DNA
• Time Factors
• Vincristine (administration & dosage)