Abstract | BACKGROUND AND AIM:
Acid suppressive therapy has been reported to regress Barrett's esophagus. However, it is still controversial as to whether all Barrett's esophagus patients respond to this therapy. The factors that might facilitate newly developed squamous re-epithelialization after biopsy excision of Barrett's mucosa were evaluated to identity individuals who may favorably respond to the regression therapy. METHODS: Two hundred and forty-seven biopsy sites from 185 patients with Barrett's esophagus were examined by endoscopy to investigate possible squamous re-epithelialization of Barrett's mucosa after endoscopic biopsy. Before endoscopic examination, all participants were requested to answer questionnaires concerning sociodemographic characteristics, lifestyle habits and drugs usage. The mucin phenotype, Cdx2 expression, cyclooxygenase-2 expression, cellular proliferation and apoptosis of Barrett's mucosa were immunohistochemically investigated in the biopsy samples taken from Barrett's esophagus. The influence of these factors on the newly developed squamous re-epithelialization of Barrett's mucosa after endoscopic biopsy excision was evaluated. RESULTS: CONCLUSIONS: The absence of the intestinal predominant mucin phenotype was a positive predictor for newly developed squamous re-epithelialization at the site of biopsy of Barrett's mucosa. Only Barrett's esophagus with the gastric predominant mucin phenotype may predict a favorable response to acid suppressive therapy.
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Authors | Yuji Amano, Yoshinori Kushiyama, Takafumi Yuki, Yoshiko Takahashi, Daisuke Chinuki, Norihisa Ishimura, Kenji Furuta, Shunji Ishihara, Kyoichi Adachi, Riruke Maruyama, Yoshikazu Kinoshita |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 22
Issue 6
Pg. 901-7
(Jun 2007)
ISSN: 0815-9319 [Print] Australia |
PMID | 17565646
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Cyclooxygenase 2 Inhibitors
- Gastric Mucins
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Topics |
- Aged
- Anti-Ulcer Agents
(therapeutic use)
- Barrett Esophagus
(drug therapy, pathology)
- Biopsy
- Carcinoma, Squamous Cell
(pathology)
- Chi-Square Distribution
- Cyclooxygenase 2 Inhibitors
(therapeutic use)
- Esophageal Neoplasms
(pathology)
- Esophagoscopy
- Female
- Gastric Mucins
(analysis)
- Humans
- Logistic Models
- Male
- Phenotype
- Predictive Value of Tests
- Risk Factors
- Surveys and Questionnaires
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