Abstract | OBJECTIVE: METHODS: Aortic specimens routinely removed during CABG surgery in 66 consecutive patients with inflammatory rheumatic disease and 51 control patients without inflammatory rheumatic disease were examined by light microscopy for the occurrence, location, and severity of chronic inflammatory infiltrates and atherosclerotic lesions. RESULTS: Mononuclear cell infiltrates in the inner adventitia (apart from those localized along the epicardium) were more frequent in the group of patients with inflammatory rheumatic disease (47% versus 20%; P = 0.002, odds ratio [OR] OR 3.6, 95% confidence interval [95% CI] 1.6-8.5), and the extent of these infiltrates was greater. Multivariate analyses revealed that the occurrence of mononuclear cell infiltrates was associated with inflammatory rheumatic disease (OR 2.99, P = 0.020) and current smoking (OR 3.93, P = 0.012), and they were observed in 6 of 7 patients with a history of aortic aneurysm. Inflammatory infiltrates in the media were seen only in patients with inflammatory rheumatic disease. The frequency of atherosclerotic lesions, inflammation within the plaques, and epicardial inflammatory infiltrates in the 2 groups was equal. CONCLUSION: Among aortic samples collected during CABG surgery, those obtained from patients with inflammatory rheumatic disease had more pronounced chronic inflammatory infiltration in the media and inner adventitia than those obtained from control patients. Current smoking was an independent predictor of chronic inner adventitial infiltrates. The infiltrates may represent an inflammatory process that promotes atherosclerosis and formation of aneurysms.
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Authors | Ivana Hollan, Helge Scott, Kjell Saatvedt, Richard Prayson, Knut Mikkelsen, Hans C Nossent, Ingjerd Lien Kvelstad, Matthew H Liang, Oystein T Førre |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 56
Issue 6
Pg. 2072-9
(Jun 2007)
ISSN: 0004-3591 [Print] United States |
PMID | 17530648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Aorta
(immunology, pathology)
- Aortic Diseases
(immunology, pathology)
- Biopsy
- Case-Control Studies
- Connective Tissue
(pathology)
- Coronary Artery Bypass
- Coronary Artery Disease
(immunology, pathology, surgery)
- Female
- Humans
- Inflammation
(etiology, pathology)
- Male
- Middle Aged
- Multivariate Analysis
- Predictive Value of Tests
- Rheumatic Diseases
(complications, pathology)
- Risk Factors
- Smoking
(adverse effects)
- Tunica Intima
(pathology)
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