Abstract |
A multicentre, randomized, blinded study compared the efficacy of pradofloxacin with that of a combination of amoxycillin/clavulanic acid in the treatment of deep pyoderma in dogs. Dogs with clinical lesions of deep pyoderma and a positive bacterial culture were included in the study. At each visit, they were evaluated with lesion, pruritus and general condition scores. Dogs were treated either with pradofloxacin at 3 mg kg-1 once daily or with amoxycillin at 10 mg kg-1 and clavulanic acid at 2.5 mg kg-1 twice daily and evaluated weekly for 3 weeks and every 2 weeks thereafter until 2 weeks past clinical remission. Maximal treatment duration was 9 weeks, and maximal evaluation period was 11 weeks. Of the 56 dogs treated with pradofloxacin (group 1), 48 dogs (86%) achieved clinical remission, four dogs improved, four dogs did not respond and a recurrence of clinical signs was not seen in any patient after 11 weeks. Of the 51 dogs treated with amoxycillin/clavulanic acid (group 2), 37 dogs achieved clinical remission (73%), three dogs showed improvement, five dogs showed no response and in six dogs, clinical signs recurred within 2 weeks of cessation of therapy. These results indicate that pradofloxacin is an efficacious therapy comparable to amoxycillin/clavulanic acid for deep bacterial pyoderma in dogs.
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Authors | Ralf S Mueller, Bernd Stephan |
Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 18
Issue 3
Pg. 144-51
(Jun 2007)
ISSN: 0959-4493 [Print] England |
PMID | 17470228
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Fluoroquinolones
- Clavulanic Acid
- pradofloxacin
- Amoxicillin
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Topics |
- Administration, Oral
- Amoxicillin
(administration & dosage, therapeutic use)
- Animals
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Clavulanic Acid
(administration & dosage, therapeutic use)
- Dog Diseases
(drug therapy, pathology)
- Dogs
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Fluoroquinolones
(administration & dosage, therapeutic use)
- Germany
- Male
- Pyoderma
(drug therapy, veterinary)
- Severity of Illness Index
- Treatment Outcome
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