HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat.

Abstract
In diabetes, postprandial hyperlipidemia is recognized as a risk factor for premature atherosclerosis and following cardiovascular disease. In the present study, features of fat absorption and clearance were examined to clarify the lipid metabolism of Spontaneously Diabetic Torii (SDT) rats. Olive oil was orally administered to evaluate increase of blood triglyceride (TG) level. Mesenteric lymph chylomicron TG was also measured. mRNAs of enzymes and transfer protein related to TG metabolism and histopathological changes were evaluated. In an oil loading test, elevation of TG in plasma and lymph chylomicron was increased in SDT rats. Interestingly, SDT rats showed elevation of plasma TG after oil loading and relatively low epididymal fat lipoprotein lipase (LPL) mRNA expression even at the pre-diabetic state without increase of TG absorption from intestine. In the diabetic state, intestines of SDT rats were hypertrophic and expressed mRNAs of enzymes and transfer protein related to TG absorption highly. From these results, it seems that intestinal abnormalities related to hypoinsulinemia/hyperglycemia cause postprandial hypertriglyceridemia in SDT rats. In addition, our findings suggest that SDT rats have impaired lipid catabolism antecedent to hypoinsulinemia/hyperglycemia. These characteristics of SDT rats can be useful in studies of diabetic hypertriglyceridemia and TG metabolism.
AuthorsTomohiko Sasase, Hisayo Morinaga, Hiromi Yamamoto, Naoto Ogawa, Kenichi Matsui, Katsuhiro Miyajima, Takashi Kawai, Yasuko Mera, Taku Masuyama, Masami Shinohara, Takeshi Ohta, Mutsuyoshi Matsushita
JournalDiabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 78 Issue 1 Pg. 8-15 (Oct 2007) ISSN: 0168-8227 [Print] Ireland
PMID17448560 (Publication Type: Journal Article)
Chemical References
  • Chylomicrons
  • Dietary Fats
  • Lipids
  • Olive Oil
  • Plant Oils
  • RNA, Messenger
  • Triglycerides
Topics
  • Animals
  • Body Weight
  • Chylomicrons (metabolism)
  • Diabetes Mellitus (genetics, metabolism)
  • Dietary Fats (pharmacokinetics)
  • Energy Intake
  • Hyperglycemia (genetics)
  • Intestinal Absorption (physiology)
  • Lipids (pharmacokinetics)
  • Male
  • Olive Oil
  • Plant Oils (pharmacokinetics)
  • RNA, Messenger (genetics)
  • Rats
  • Rats, Mutant Strains
  • Triglycerides (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: