Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide.

Abstract

UNLABELLED:

Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.

CONCLUSION:

four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.

• Authors: Brian A Vesely, Ehrentraud J Eichelbaum, Abdel A Alli, Ying Sun, William R Gower Jr, David L Vesely
• Journal: Cancer letters (Cancer Lett) Vol. 254 Issue 1 Pg. 94-101 (Aug 28 2007) ISSN: 0304-3835 [Print] Ireland
• PMID: 17399891 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Peptide Fragments
• Peptides
• Protein Precursors
• atrial natriuretic factor precursor (79-98)
• atrial natriuretic factor prohormone (1-30), human
• atrial natriuretic factor prohormone (31-67)
• Atrial Natriuretic Factor
• Receptors, Atrial Natriuretic Factor

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Atrial Natriuretic Factor (pharmacology)
• Blotting, Western
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• DNA, Neoplasm (biosynthesis)
• Dose-Response Relationship, Drug
• Elapidae (metabolism)
• Glioblastoma (genetics, metabolism, pathology)
• Humans
• Myocardium (chemistry, metabolism)
• Peptide Fragments (pharmacology)
• Peptides (pharmacology)
• Protein Precursors (pharmacology)
• Receptors, Atrial Natriuretic Factor (metabolism)
• Time Factors