Abstract | INTRODUCTION: AIM: The aim of the present study was to evaluate if oral cryotherapy could delay or alleviate the development of mucositis and thereby reduce the number of days with i.v. opioids among patients who receive myeloablative therapy before BMT. MATERIALS AND METHODS: Eighty patients 18 years and older, scheduled for BMT, were included consecutively and randomised to oral cryotherapy or standard oral care. A stratified randomisation was used with regard to type of transplantation. Intensity of pain, severity of mucositis and use of opioids were recorded using pain visual analogue scale (VAS) scores, mucositis index scores and medical and nursing charts. RESULTS: This study showed that patients receiving oral cryotherapy had less pronounced mucositis and significantly fewer days with i.v. opioids than the control group. In the autologous setting, cryotherapy patients also needed significantly lower total dose of opioids. CONCLUSION: Oral cryotherapy is an effective and well-tolerated therapy to alleviate mucositis and consequently reduce the number of days with i.v. opioids among patients treated with myeloablative therapy before BMT.
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Authors | Anncarin Svanberg, Gunnar Birgegård, Kerstin Ohrn |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 15
Issue 10
Pg. 1155-61
(Oct 2007)
ISSN: 0941-4355 [Print] Germany |
PMID | 17393189
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Myeloablative Agonists
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Topics |
- Adult
- Analgesics, Opioid
(therapeutic use)
- Bone Marrow Transplantation
- Cryotherapy
(methods)
- Female
- Humans
- Male
- Middle Aged
- Myeloablative Agonists
(therapeutic use)
- Stomatitis
(prevention & control)
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