Abstract | BACKGROUND: Many individuals allergic to peanuts have multiple allergen sensitivity. OBJECTIVE: To report the first case, to our knowledge, of a peanut allergic patient who exhibited cosensitivity to citrus seeds and who had experienced anaphylaxis to lemon soap. METHODS: Extracts of peanut and seeds from different varieties of citrus fruit (orange, lemon, and mandarin) were prepared and resolved with 14% sodium dodecyl sulfate- polyacrylamide gel electrophoresis. Direct and inhibition immunoblotting of the patient's serum on the extracts was used to examine the pattern of IgE reactivity and the presence of cross-reactive allergens. RESULTS: Numerous IgE reactive proteins were demonstrated in each citrus seed extract and the peanut extract. Complete IgE cross-reactivity was demonstrated among the different citrus seed extracts. Partial cross-reactivity was demonstrated between the peanut and orange seed extracts. CONCLUSIONS: Citrus seeds contain numerous IgE reactive proteins that are completely cross-reactive among orange, lemon, and mandarin. When peanut allergy coexists with citrus seed allergy, IgE cross-reactivity between peanut and citrus seed proteins can be demonstrated, suggesting a basis to this cosensitivity.
|
Authors | Ian N Glaspole, Maria P de Leon, Jennifer M Rolland, Robyn E O'Hehir |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 98
Issue 3
Pg. 286-9
(Mar 2007)
ISSN: 1081-1206 [Print] United States |
PMID | 17378262
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Allergens
- Plant Extracts
- Soaps
|
Topics |
- Adult
- Allergens
(immunology)
- Anaphylaxis
(immunology)
- Arachis
(immunology)
- Citrus
(immunology)
- Cross Reactions
- Humans
- Male
- Peanut Hypersensitivity
(immunology)
- Plant Extracts
(immunology)
- Seeds
(immunology)
- Soaps
(adverse effects)
|