Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome.
|
| Abstract | BACKGROUND: Human herpesvirus 6 (HHV-6) reactivation has been suggested to modify the clinical features of drug induced hypersensitivity syndrome (DIHS). However, mechanisms for viral reactivation and modification of the clinical features remain unclear. OBJECTIVE: To determine whether cytokines play an important role in viral reactivation and modification of the clinical features. STUDY DESIGN: We examined the kinetics of serum cytokines and viral load in HHV-6 infections of six patients with DIHS. RESULTS: HHV-6 infection occurred three to four weeks after the onset of disease. Elevated TNF-alpha and IL-6 levels were observed to precede HHV-6 infection in four of the six patients. Although high levels of IL-6 were observed in samples collected prior to HHV-6 infection, the amounts of this cytokine significantly decreased to undetectable levels during viral infection in five of the six patients. Subsequently, serum IL-6 levels were increased after viral infection in five patients. IL-1beta levels were also increased at the time of viral infection in three of the six patients. Neither IL-4 nor IFN-gamma could be detected in any of the samples. CONCLUSION: These results demonstrate that cytokines play an important role in HHV-6 reactivation in patients with DIHS.
|
|---|---|
| Authors | Tetsushi Yoshikawa, Ayano Fujita, Akiko Yagami, Kayoko Suzuki, Kayoko Matsunaga, Masaru Ihira, Yoshizo Asano |
| Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (J Clin Virol) Vol. 37 Suppl 1 Pg. S92-6 (Dec 2006) ISSN: 1386-6532 [Print] Netherlands |
| PMID | 17276377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!