Abstract | BACKGROUND: METHODS: (1) Tumor burden experiments: Animals bearing one or more tumors greater than 10 mm in diameter were treated for 56 consecutive days with 20 mg/kg or 80 mg/kg of liarozole by oral gavage, tamoxifen 100 mug/kg by subcutaneous injection, or a combination of liarozole and tamoxifen. At the end of the treatment period, total cumulative tumor volume as well as retinoic acid levels were measured. (2) Uterotrophic assay and proliferation experiments: 21-day-old ovariectomized (OVX) Sprague-Dawley rats were treated with 20 mg/kg or 80 mg/kg of liarozole by oral gavage, tamoxifen 1 mg/kg by subcutaneous injection, and combination of both for 4 consecutive days. At the end of the treatment period, uterine weight, epithelial lining cell height and indices of proliferation cell nuclear antigen ( PCNA) were measured. RESULTS: CONCLUSION:
Liarozole's antitumor effects on ER positive mammary tumors and its protective effect on the uterus merit further studies to confirm its clinical value in combination with tamoxifen in ER positive postmenopausal breast cancer. Liarozole and other retinomimetics might also be suitable chemoprevention drugs in combination with tamoxifen because of their favorable toxicity profile.
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Authors | Paul E Goss, Kathrin Strasser-Weippl, Shangle Qi, Haiqing Hu |
Journal | BMC cancer
(BMC Cancer)
Vol. 7
Pg. 26
(Jan 31 2007)
ISSN: 1471-2407 [Electronic] England |
PMID | 17266767
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Imidazoles
- Tamoxifen
- Methylnitrosourea
- liarozole
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Topics |
- Animals
- Breast Neoplasms
(chemically induced, drug therapy, pathology)
- Cell Proliferation
- Disease Models, Animal
- Drug Therapy, Combination
- Female
- Imidazoles
(administration & dosage, pharmacology, therapeutic use)
- Methylnitrosourea
(pharmacology)
- Ovariectomy
- Rats
- Rats, Sprague-Dawley
- Tamoxifen
(administration & dosage, pharmacology, therapeutic use)
- Uterus
(cytology, drug effects)
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