Abstract |
Although different treatment modalities have been implemented for pulmonary fibrosis, the results have not been promising and these conditions have been considered untreatable and irreversible. Thus, a plethora of new drugs has been tried for the control of this condition in recent years. This study examined the effects of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on paraquat-induced pulmonary fibrosis in rats, through biochemical and histopathological parameters. Male albino Wistar rats were divided into eight groups (n = 4-5 each), including control, paraquat, captopril alone, captopril treatment and pre-treatment, enalapril alone, enalapril treatment and pre-treatment. After 21 days of treatment, the lungs were removed and the levels of hydroxyproline, glutathione and lipid peroxidation were determined. Angiotensin-converting enzyme inhibitors showed no effect on glutathione and lipid peroxidation. The results also demonstrated that captopril and enalapril improved pulmonary fibrosis as shown by histopathology, as well as a decreased content of hydroxyproline (P < 0.001) in the lung tissue. In conclusion, the present findings suggest that the antifibrotic effect of these drugs may be related to the inhibition of angiotensin-converting enzyme.
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Authors | Mahmoud Ghazi-Khansari, Ali Mohammadi-Karakani, Masoud Sotoudeh, Parvin Mokhtary, Ebraheim Pour-Esmaeil, Shirin Maghsoud |
Journal | Journal of applied toxicology : JAT
(J Appl Toxicol)
2007 Jul-Aug
Vol. 27
Issue 4
Pg. 342-9
ISSN: 0260-437X [Print] England |
PMID | 17265423
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2007 John Wiley & Sons, Ltd. |
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Herbicides
- Enalapril
- Collagen
- Captopril
- Glutathione
- Paraquat
- Hydroxyproline
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Topics |
- Administration, Oral
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Animals
- Captopril
(administration & dosage, therapeutic use)
- Collagen
(metabolism)
- Dose-Response Relationship, Drug
- Enalapril
(administration & dosage, therapeutic use)
- Glutathione
(metabolism)
- Herbicides
(administration & dosage, toxicity)
- Hydroxyproline
(metabolism)
- Injections, Intraperitoneal
- Lipid Peroxidation
(drug effects)
- Lung
(drug effects, metabolism, pathology)
- Male
- Paraquat
(administration & dosage, toxicity)
- Pulmonary Alveoli
(drug effects, metabolism, pathology)
- Pulmonary Fibrosis
(chemically induced, drug therapy)
- Rats
- Rats, Wistar
- Time Factors
- Treatment Outcome
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