Abstract |
Impaired fasting glucose (IFG) represents risk of development of diabetes (DM) and its complications. We investigated insulin secretion and insulin sensitivity in 403 IFG subjects divided into three levels of 2-hour postchallenge glucose (2-h PG) to clarify the factors responsible in the development of glucose intolerance in Japanese IFG. Nearly 60% of the subjects at annual medical check-up with FPG of 6.1-7.0 mmol/l at the first screening were diagnosed by 75 g oral glucose tolerance test (OGTT) to have impaired glucose tolerance (IGT; FPG <7.0 mmol/l and 7.8 mmol/l <2-h PG <11.1 mmol/l) or DM (isolated postchallenge hyperglycemia (IPH); FPG <7.0 mmol/l and 11.1 mmol/l <2-h PG level). The primary factor in the decreased glucose tolerance was a decrease in early-phase insulin, with some contribution of increasing insulin resistance. In addition, IFG/IGT and IFG/IPH subjects showed a compensatory increase in basal insulin secretion sufficient to keep FPG levels within the non-diabetic range. IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity.
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Authors | M Izuka, M Fukushima, A Taniguchi, Y Nakai, H Suzuki, T Kawakita, S Kawamata, O Kajimoto, K Tsuda, N Nagaki, M Murakami, Y Seino |
Journal | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
(Horm Metab Res)
Vol. 39
Issue 1
Pg. 41-5
(Jan 2007)
ISSN: 0018-5043 [Print] Germany |
PMID | 17226112
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Asian People
- Blood Glucose
(analysis)
- Fasting
(blood)
- Glucose Intolerance
(etiology)
- Glucose Tolerance Test
- Humans
- Hyperglycemia
(blood)
- Insulin
(metabolism)
- Insulin Resistance
- Insulin Secretion
- Middle Aged
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