Amiodarone pulmonary toxicity: a patient with three recurrences of pulmonary toxicity and consideration of the probable risk for relapse.

Abstract

A 44-year-old man was treated with amiodarone for dilated cardiomyopathy. After 53 months, he developed amiodarone-induced interstitial pneumonia. Amiodarone treatment was terminated, and the patient was given corticosteroids. These treatments were effective. However, pneumonitis recurred whenever prednisolone was reduced to less than 5 mg per day. Considering the patient's background characteristics, we considered his body mass index (BMI, kg/m(2)) and found his to be high. When four additional patients with amiodarone pulmonary toxicity were reviewed at our institute, a correlation between BMI and the duration of shadow disappearance was found (R(2)=0.8695). Because amiodarone is lipophilic, the patient's high BMI might have influenced the repeated appearance of pulmonary toxicity.

• Authors: Kaori Okayasu, Yuichiro Takeda, Jun Kojima, Atsuto Yoshizawa, Nobuyuki Kobayashi, Haruhito Sugiyama, Koichiro Kudo
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 22 Pg. 1303-7 ( 2006) ISSN: 1349-7235 [Electronic] Japan
• PMID: 17170505 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Anti-Inflammatory Agents
• Prednisolone
• Amiodarone

Topics

• Adult
• Amiodarone (adverse effects, therapeutic use)
• Anti-Arrhythmia Agents (adverse effects, therapeutic use)
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Body Mass Index
• Cardiomyopathy, Dilated (drug therapy, pathology)
• Dose-Response Relationship, Drug
• Humans
• Lung Diseases, Interstitial (chemically induced, diagnostic imaging, drug therapy)
• Male
• Prednisolone (administration & dosage, therapeutic use)
• Radiography, Thoracic
• Recurrence
• Retreatment
• Tomography, X-Ray Computed